|講演題目||Modeling Critical Steps in Function and Disease|
|講演者||Professor Hanry Yu
Professor, Physiology and Mechanobiology, National University of Singapore
|概要||●Abstract: Plethora of devices mimicking anatomical structures or context-less phenotypes are seldom useful in application. Successful devices recapitulate the critical steps in function and disease processes. We use a mechanobiology framework to dissect the complex process of bile canaliculi contraction in normal liver and in obstructive cholestasis. The critical events switching between successive steps are natural targets for drug discovery. In another example, human stem cells model the human embryonic development. Teratogens were identified for disrupting cell differentiation and migration in one critical step of the mesoendoderm formation. Such context-specific assay performs better than the metabolic profiles of undifferentiated stem cells or the assay measuring the disruption of the entire process leading to cardiomyocyte beating. Finally, a patient-derived organoid (PDO) in wells/on chips model the non-alcoholic steatohepatitis (NASH) by expressing key phenotypes of the disease. Identifying critical phenotypes and the corresponding functional modules to model NASH represent the most important tasks in the development of a simple, robust and effective device useful for applications.
●Biography: Professor Hanry Yu translates basic knowledge and technology into solutions for industry, integrating mechanobiology, biomaterials, regenerative medicine, lab-on-chip, biomedical optics and image data analytics. He delivered >180 invited talks, published >180 journal articles, >250 conference papers, >50 patent applications; co-founded 6 companies. He has taught many students in Singapore, Hong Kong, and top US universities such as MIT, Columbia, Penn, U of California system, and 5 others. He has led multiple programs/institutions; and advises various agencies, and organizations worldwide. Professor Yu is currently a professor of physiology and mechanobiology at the National University of Singapore; a group leader at the A*STAR; Co-Lead PI at the CAMP IRG, Singapore-MIT Alliance for Research and Technology (SMART). He is a handling editor of Biomaterials.