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(キャンセルとなりました)第344回化学システム工学専攻公開セミナー Digitalization platform and supervisory control for continuous integrated manufacture of monoclonal antibodies

2019年9月19日(木) 10:30-12:00
講演題目 Digitalization platform and supervisory control for continuous integrated manufacture of monoclonal antibodies
講演者 Prof. Massimo Morbidelli
Department of Chemistry, Materials and Chemical Engineering Politecnico di Milano, Milano, Italy and Department of Chemistry and Applied Biosciences ETH Zurich, Zurich, Switzerland
概要 In the last years, there has been an increased interest in continuous and integrated manufacturing of biopharmaceuticals, due to increasing cost and time pressure in industry as well as diversifying pipelines asking for more flexible production concepts. However, we are still far from an efficient implementation of modern process analyzers, a centralized data mining combined with online use of advanced analysis algorithms and the integration of process knowledge into a supervisory control frame.

In this contribution, we present an automated end-to-end integrated platform for the production of a monoclonal antibody. The process consists of a perfusion bioreactor, a continuous protein A capture step, which is followed by low-pH virus inactivation, and frontal and flow-through chromatographic steps for final polishing. Automated at-line HPLC systems equipped with protein A and size exclusion columns give insight into critical process parameters without the necessity of manual sampling. Additionally, the potential of Raman spectroscopy was investigated in USP and a flow cell was developed to enable important real-time information from downstream units.
The presented results will show the need for an efficient process data collection and hierarchical control system to handle process perturbations and drifts, facilitating robust product yield and quality. The presented concept provides a very important basis to intensify the main advantages of continuous integrated manufacturing in agreement with the trends of industry 4.0.
世話人 杉山 弘和(内線:27227)

第343回化学システム工学専攻公開セミナー Supercritical fluid technology: a scalable approach for advanced material design and recycling What is about sustainability?

2019年10月3日(木) 15:00-17:00
講演題目 Supercritical fluid technology: a scalable approach for advanced material design and recycling What is about sustainability?
講演者 Prof. Cyril Aymonier
Institute for Solid State Chemistry Bordeaux(ICMCB), CNRS and University of Bordeaux
概要 Supercritical fluid flow synthesis technologies are developed from the beginning of the 90’s in the field of advanced materials by design.
This technology of material processing is continuous, fast (few tens of seconds), sustainable and scalable and gives access to high quality nanostructured materials with unique physico-chemical properties, meaning which can not be obtained with other synthetic methods.

After a brief introduction on supercritical fluids, this presentation proposes to describe the principle of the preparation of advanced materials using this continuous process. A focus will be proposed on the in situ characterizations developed in the last 10 years to be able to understand, model but also to master the formation of nanostructures in supercritical fluids. As an illustration, we will present the first proof of the synthesis in few tens of seconds of geominerals, namely talc, in a continuous millifluidic process. Very interestingly, this synthetic talc exhibits unique properties as its hydrophilicity knowing that naturel talc is hydrophobic. In this new field of geomineral synthesis, we went one-step forward with the demonstration of the possibility to prepare highly crystalline geominerals in just few seconds again but under thermodynamically metastable conditions with the synthesis of the torbermorite mineral which is not abundant in nature but very interesting in the construction industry. The mastering of the chemistry coupled with one pot multi-step processes opens the road towards the continuous design of multifunctional materials as illustrated with functional layer double hydroxide. All these materials can now be produced from laboratory scale for research & development investigations to pilot scale for industrial purposes.

Beyond the design of advanced nanostructured materials, near- and supercritical fluids are also powerful reaction media to offer innovative processes in the field of material recycling. This will be illustrated with the recycling of carbon fibres from carbon fibre reinforced polymers (CFRPs). Compared to pyrolysis, fluidized bed and low temperature processes, which are other studied approaches for CFRPs, solvolysis in near- or supercritical fluids is a great alternative to recover fibres as it provides a high retention of mechanical properties and fibre length and a high potential for material recovery from resin.
Other examples will concern the recycling of scrap magnets and food packaging.

The benefits of the sub- and supercritical continuous route include not only better performances for advanced applications but also environmental issues associated with the synthesis process. This will be emphasized with the studies performed using LCA approaches coupled with risk assessment ones.
世話人 平尾 雅彦(内線:27387)

第342回化学システム工学専攻公開セミナー シロキサン系物質の無機合成化学

講演題目 シロキサン系物質の無機合成化学
講演者 黒田一幸教授
概要 黒田一幸教授は,これまで一貫してシリカ・ケミストリーに係る無機合成化学に従事されてきた。特に特筆すべきは,「メソポーラス物質」として現在広く世に知らしめることとなった,メソ孔(IUPAC定義で2~50ナノメートル)範囲に均質な細孔をもつメソポーラス・シリカFSM-16を,豊田中央研究所と共同創出したことである。層状化合物である粘土(2次元)から始まったご研究が, その後のメソ空間素材の発展の歴史だけに留まらず, 低次元(1次元鎖状シリケート)から高次元(3次元ナノシリケート)へと次元を超えたシリカ・ケミストリーへと発展されてきた。この根底にある基礎合成化学から,応用研究に至るまでの,黒田教授のご研究の一端を本特別講義にて御講義いただく。
世話人 小倉 賢(内線56321)

第341回化学システム工学専攻公開セミナー Engineering Hydrogels with Unprecedented Properties for Soft Tissue Repair

東京大学 本郷キャンパス 臨床研究棟A 9F 談話室(914号室)
講演題目 Engineering Hydrogels with Unprecedented Properties for Soft Tissue Repair
講演者 Professor Jianyu Li
Assistant Professor of Mechanical Engineering Associate Member of Biomedical Engineering McGill University, Montreal, Canada
概要 ●Abstract: Biomaterials find broad use in many branches of medicine. Success examples include hard biomaterials in dentistry and prosthetics. Soft biomaterials, however, haven’t replicated these successes in repairing soft tissues. The reason is simple yet fundamental: existing materials like hydrogels cannot match or integrate with soft tissues mechanically; they are often vulnerable to rupture and difficult to adhere on soft tissues, especially when interfacing with dynamic tissues such as skin and beating heart. This talk will present new strategies and material systems to overcome these material constraints. Two types of bioinspired hydrogel adhesives will be presented. One can be tougher than articular cartilage and achieve unprecedented adhesion performance on a variety of soft tissues, even under exposure of blood and dynamic movements. The other can actively contract and heal skin wound effectively. This talk will highlight how to leverage mechanical principles and bioinspired concepts to engineer novel biomaterials with unprecedented properties, enabling and impacting applications of tissue repair and regeneration.

●Biography: Prof. Jianyu Li is an Assistant Professor in the Department of Mechanical Engineering and an Associate Member in the Department of Biomedical Engineering at McGill University since September 2017. In the past, he obtained his bachelor’s degree from Zhejiang University in 2010. He obtained a Ph.D. degree in Materials Science and Mechanical Engineering under the supervision of Prof. Zhigang Suo and Prof. Joost J. Vlassak from Harvard University in 2015. He did postdoctoral research with Prof. David Mooney at the Harvard Wyss Institute for Biologically Inspired Engineering from 2015 to 2017. He was the recipient of Wyss Technology Development Award for enabling translational research. He has published papers in journals such as Science, Science Advances, Nature Reviews Materials, and Nature Communications. His work has been highlighted by the New England Journal of Medicine and profiled by BBC, PBS, NPR, The Washington Post, etc. His research interests focus on design and mechanics of soft biomaterials and their applications in tissue repair and regeneration.
世話人 伊藤 大知(内線21425)

第340回化学システム工学専攻公開セミナー Modeling Critical Steps in Function and Disease

講演題目 Modeling Critical Steps in Function and Disease
講演者 Professor Hanry Yu
Professor, Physiology and Mechanobiology, National University of Singapore
概要 ●Abstract: Plethora of devices mimicking anatomical structures or context-less phenotypes are seldom useful in application. Successful devices recapitulate the critical steps in function and disease processes. We use a mechanobiology framework to dissect the complex process of bile canaliculi contraction in normal liver and in obstructive cholestasis. The critical events switching between successive steps are natural targets for drug discovery. In another example, human stem cells model the human embryonic development. Teratogens were identified for disrupting cell differentiation and migration in one critical step of the mesoendoderm formation. Such context-specific assay performs better than the metabolic profiles of undifferentiated stem cells or the assay measuring the disruption of the entire process leading to cardiomyocyte beating. Finally, a patient-derived organoid (PDO) in wells/on chips model the non-alcoholic steatohepatitis (NASH) by expressing key phenotypes of the disease. Identifying critical phenotypes and the corresponding functional modules to model NASH represent the most important tasks in the development of a simple, robust and effective device useful for applications.

●Biography: Professor Hanry Yu translates basic knowledge and technology into solutions for industry, integrating mechanobiology, biomaterials, regenerative medicine, lab-on-chip, biomedical optics and image data analytics. He delivered >180 invited talks, published >180 journal articles, >250 conference papers, >50 patent applications; co-founded 6 companies. He has taught many students in Singapore, Hong Kong, and top US universities such as MIT, Columbia, Penn, U of California system, and 5 others. He has led multiple programs/institutions; and advises various agencies, and organizations worldwide. Professor Yu is currently a professor of physiology and mechanobiology at the National University of Singapore; a group leader at the A*STAR; Co-Lead PI at the CAMP IRG, Singapore-MIT Alliance for Research and Technology (SMART). He is a handling editor of Biomaterials.
世話人 酒井 康行(内線27073)

第339回化学システム工学専攻公開セミナー コロイド分散系の数値シミュレーション-膜分離プロセスへの応用-

2019年3月12日(火) 17:30-18:30
東京大学 本郷キャンパス 臨床研究棟A 9F 談話室(914号室)
講演題目 コロイド分散系の数値シミュレーション-膜分離プロセスへの応用-
講演者 三野 泰志
岡山大学大学院自然科学研究科応用化学専攻 助教
概要 コロイド分散系の流れの理解・制御は様々な工業プロセスにおいて必要とされている。そのためのアプローチとして、近年、数値シミュレーションが用いられることが増えつつある。講演者は、数値流体シミュレーション手法の一つ、格子ボルツマン法(Lattice Boltzmann Method)を用いたコロイド分散液の流れシミュレーション技術の開発と膜分離プロセスへの応用を行ってきた。本講演では、コロイド分散系の数値シミュレーションの基本モデルについて、格子ボルツマン法を中心に説明するとともに、これまで行ってきた膜分離プロセス(膜ろ過、油水分離コアレッサー)の解析例について紹介する。また、数値シミュレーションを利用する際の注意点や問題点など、通常、学会発表や論文ではあまり言及されることのない点についても説明する。
世話人 伊藤大知 (内線21425)

第338回化学システム工学専攻公開セミナー Halide Perovskites: The New Wonder Photovoltaic Material

2019年3月11日(月) 13:00-15:00
講演題目 Halide Perovskites: The New Wonder Photovoltaic Material
講演者 Prof. Tze-Chien SUM,
Nanyang Technological University, Singapore.
概要 Organic-Inorganic halide perovskite solar cells are presently the forerunner amongst the solution-processed photovoltaic technologies with efficiencies exceeding 23%. In this talk, I will review the photophysical mechanisms of the workhorse CH3NH3PbI3 system. In addition, I will highlight some of our findings of slow hot hole cooling phenomenon in halide perovskites [1]. Our group further uncovered that hot electrons cooling is slow as well and is relatively balanced with the hot holes. [2] I will also focus on our group’s efforts: (i) to further retard the hot carrier cooling using perovskite nanoparticles; (ii) to achieve efficient extraction of the hot carriers; [3] and (iii) to understand origins and mechanisms of slow hot-carrier cooling in halide perovskites [4]. Opportunities and challenges for hot-carrier perovskite photovoltaics will also be discussed.

[1] G. C. Xing, N. Mathews, S. Sun, S. S. Lim, Y. M. Lam, M. Graetzel, S. Mhaisalkar and T. C. Sum*, “Long-Range Balanced Electron and Hole Transport Lengths in Organic-Inorganic CH3NH3PbI3”, Science, 342 (6156) 344-347 (2013)
[2] T. C. Sum*, N. Mathews, G. Xing, S. S. Lim, W. K. Chong, D. Giovanni, H. A. Dewi, “Spectral Features and Charge Dynamics of Lead Halide Perovskites: Origins and Interpretations (Invited Article)”, Accounts of Chemical Research 49 (2) 294-302 (2016),
[3] M. J. Li, S. Bhaumik, T. W. Goh, M. S. Kumar, N. Yantara, M. Graetzel, S. G. Mhaisalkar, N. Mathews, and T. C. Sum*, “Slow Cooling and Highly Efficient Extraction of Hot Carriers in Colloidal Perovskite Nanocrystals”, Nature Communications 8 14350 (2017)
[4] J. Fu, Q. Xu, G. Han, B. Wu, C. H. A. Huan, M. L. Leek & T. C. Sum*, “Hot carrier cooling mechanisms in halide perovskites”, Nature Communications 8:1300 (2017)

世話人 岸本史直 大久保・脇原研(内線:27368)

第337回化学システム工学専攻公開セミナー Molecular approaches and H2 technologies

2019年1月31日(木) 15:00-17:00
東京大学 本郷キャンパス 工学部5号館 337室(第4輪講室)
講演題目 Molecular approaches and H2 technologies
講演者 Prof. Vincent Artero
Universite Grenoble Alpes, CNRS, CEA
概要 New directions are urgently needed in energy technologies, and in particular in hydrogen technologies, to raise efficiency and stability of the systems while lowering their cost. Bio-inspiration has a great potential to making breakthroughs in research and development. In particular hydrogenase enzymes compete with platinum as catalysts for H2/H+ interconversion and such an activity can be reproduced in synthetic mimics [1] but such molecular systems are often challenged by solid-state catalysts, both in terms of activity and stability. We will show how the immobilization of biomimics onto surfaces allows the preparation of highly active electrode materials compatible with existing PEM electrolysis technology [2]. Besides, we will also revisit the structure of reactivity of amorphous molybdenum sulfide, which actually stands as a coordination polymer, therefore bridging the molecular and soli-state sides of H2/H+ catalysis [3]. Besides, we will also describe our effort towards the combination of such catalysts with various photoactive motifs for the preparation of photoelectrode materials that can be implemented into photoelectrochemical (PEC) cells for water splitting [4-7].

[1] N. Coutard, N. Kaeffer, V. Artero, Molecular engineered nanomaterials for catalytic hydrogen evolution and oxidation, Chem. Commun., 52 (2016) 13728-13748.
[2] F. Jaouen, D. Jones, N. Coutard, V. Artero, P. Strasser, A. Kucernak, Toward Platinum Group Metal-Free Catalysts for Hydrogen/AirProton-Exchange Membrane Fuel Cells, Johnson Matthey Technology Review, 62 (2018) 231-255.
[3] P.D. Tran, T.V. Tran, M. Orio, S. Torelli, Q.D. Truong, K. Nayuki, Y. Sasaki, S.Y. Chiam, R. Yi, I. Honma, J. Barber, V. Artero, Coordination polymer structure and revisited hydrogen evolution catalytic mechanism for amorphous molybdenum sulfide, Nat. Mater., 15 (2016) 640-646.
[4] N. Kaeffer, C.D. Windle, R. Brisse, C. Gablin, D. Leonard, B. Jousselme, M. Chavarot-Kerlidou, V. Artero, Insights into Mechanism and Aging of a noble-metal free H2-evolving Dye-Sensitized Photocathode, Chem. Sci., 9 (2018) 6721?6738.
[5] N. Queyriaux, N. Kaeffer, A. Morozan, M. Chavarot-Kerlidou, V. Artero, Molecular cathode and photocathode materials for hydrogen evolution in photoelectrochemical devices, J. Photochem. Photobiol. C,
25 (2015) 90-105.
[6] N. Kaeffer, J. Massin, C. Lebrun, O. Renault, M. Chavarot-Kerlidou, V. Artero, Covalent Design for Dye-Sensitized H2-Evolving Photocathodes Based on a Cobalt Diimine?Dioxime Catalyst, J. Am. Chem. Soc., 138 (2016) 12308-12311.
[7] C.D. Windle, J. Massin, M. Chavarot-Kerlidou, V. Artero, A protocol for quantifying hydrogen evolution by dye-sensitized molecular photocathodes and its implementation for evaluating a new covalent architecture based on an optimized dye-catalyst dyad, Dalton Trans., 47 (2018) 10509-10516.
世話人 堂免 一成(内線:21148)

第336回化学システム工学専攻公開セミナー Tools for Accelerated Medical Innovation

2019年1月23日(水) 15:00-16:00
東京大学 本郷キャンパス 臨床研究棟A 9F 談話室(914号室)
講演題目 Tools for Accelerated Medical Innovation
講演者 Jeff Karp B.Eng. PhD.
Professor of Medicine
Brigham and Women’s Hospital
60 Fenwood Rd, Boston. 02115
概要 When developing technologies to solve medical problems, often one encounters significant hurdles, that at times seem insurmountable. Overcoming these hurdles requires new ways of thinking. One approach is to turn to nature for inspiration. Millions and millions of years of research and development at our fingertips, and all we need to do is look outside to the amazing creatures that inhabit our planet. This talk will explore medical technologies being developed that harness lessons from nature for inspiration, from creatures such as geckos, spider webs, jellyfish, porcupine quills, snails, to spiny headed worms. Another approach is radical simplicity ? the art and discipline of reducing a problem to its essence. This tool has been harnessed to develop a new skin care approach that is advancing towards global market adoption, and therapeutic strategies to combat inflammatory bowel disease and arthritis that are advancing towards clinical studies. Some of the technologies that will be described are rapidly advancing to the clinic and some are already on the market helping patients. This talk opens new paths to the continual innovation that is so important in our fast-changing world.
世話人 伊藤 大知(内線21425)

第335回化学システム工学専攻公開セミナー 伝統技術にひそむ日本人のものづくり -感性と科学-

東京大学 本郷キャンパス 工学部5号館第4輪講室(337号室)
講演題目 伝統技術にひそむ日本人のものづくり -感性と科学-
講演者 黒田孝二 博士
概要  カラー印刷画像は10~200μmの黄赤藍墨インキの微細な網点で構成され、インキの転移速度は1ミリ秒以下と高速でとても視認できないが、現場にはこれを見立てる勘と操るコツがある。70年代の日本の半導体技術の発展は現場の暗黙知に品質管理工学が融合した成果で、液晶技術の発展は液晶材料、表示セル、IC回路、組立てシステムの各産業の現場技術が融合した成果とみることができる。今も日本の現場は体感で得た技術資産が蓄積された暗黙知の宝庫である。本講演では、印刷産業に分析センターを創設し移動分析車と高速VTRで現場目線の課題解決を目指した経験をもとに、卓越した先人の感性が育んだ伝統技術にひそむ工学要素の解明の試みを紹介する。
世話人 辻 佳子(内線20909)