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第354回化学システム工学専攻公開セミナー Introduction of Additive Manufacturing Promotion Program and the Development of Digital Dentistry in Taiwan

日時
2020年1月16日(木)15:00-16:30
場所
東京大学工学部3号館大会議室3 (6C04号室)
講演題目 Introduction of Additive Manufacturing Promotion Program and the Development of Digital Dentistry in Taiwan
講演者 Cho-Pei JIANG, Professor
Department of Mechanical Engineering
National Taipei University,
Taiwan
概要 Ministry of Science and Technology (MOST) of Taiwan begins to promote the development of additive manufacturing (AM) since 2013 in the applications of aerospace, medical device and system integration. The outcome of this program has spinoff 8 new companies and published many journal papers. The author focuses on the development of digital dentistry which consisting of model reconstruction, restoration device design, biocompatible and photo-curable resin, and multi-resin printer for dental restoration device fabrication. Acknowledging for MOST financial support, a novel intra-oral scanner is developed to design the model of complete denture. Four resins have obtained the tFDA certificate and two of them has submitted to FDA in US. A multi-vat stereolithography has been developed and printing the designed complete denture model for clinical use. Furthermore, zirconia is widely used in dental and orthopedics application such as permanent dental crown and bone graft. Therefore, a novel zirconia slurry printing technology is also proposed to fabricate the customized replacement with complex structure. High dense zirconia crowns with varying shapes can be obtained by one pass fabrication. The cost is lower than using CAD/CAM system. Consequently, we spinoff two companies to promote the digital dentistry in Taiwan and spread it worldwide.
世話人 酒井 康行(内線27073)

第353回化学システム工学専攻公開セミナー 化学システム工学分野における最新シミュレーション

日時
2020年1月23日(水) 15:00-16:30
場所
東京大学工学部3号館大会議室1 (6C07号室)
講演題目 化学システム工学分野における最新シミュレーション
講演者 計測エンジニアリングシステム株式会社 第一技術部 福川真
概要 化学工学における数理モデリングは、主にプラントのプロセス設計を行うために発展してきたが、近年では先端デバイス開発、医療分野、エネルギー分野など様々な先端産業分野に拡大し、デジタル革命の到来に伴ってその技術開発競争が加速している。そのため、これからの化学産業において、複数の物理および化学の原理を用いたシステム設計や既存では扱ってこなかった異分野技術の融合が求められる。このような複雑な系を理解する方法として数値シミュレーションの重要性は高まっている。そこで、本講演では有限要素法(FEM)を用いた最新の数値シミュレーションを利用した物理現象のモデリングおよび物理現象の可視化、現象理解の方法に関する実例を紹介し、これらが先端技術の研究開発における新しいプラットフォームになりうることを示す。
世話人 吉江 建一 (内線27352)

第352回化学システム工学専攻公開セミナー Optimization Based Chemometrics

日時
2019年12月12日(木)10:00-11:30
場所
工学部3号館大会議室2(6C06号室)
講演題目 Optimization Based Chemometrics
講演者 Eli Lilly
Dr. Salvador Garcia-Munoz
概要 The development of chemometric methods for decades has followed a pattern of creating “iterative based methods” to identify the parameters of an empirical model; perhaps based on power and simplicity of the NIPALS algorithm. Such algorithms have the benefit of being relatively fast and easy to implement in a computer system since they use a very basic set of operations (additions, multiplications, a root square here and there). In the presenter’s view the most robust and powerful methods are those where the iterative algorithmic process can be proven to yield the same solution as the one found by analytically solving the objective function behind the method being parametrized.

There are situations though where these iterative methods will only find a sub-optimal for the parameter estimation problem (e.g. when data has missing samples) or will simply fail to obtain one due to the ill-conditioned nature of the matrices involved. In these cases, the simplicity of the iterative method has a cost, a sub-optimal (or non-existent) solution.

Optimization technology is at a point where problems with massive degrees of freedom can be solved. The definition of “simplicity” when it comes to solving mathematical problems has obviously moved since the days of the Intel 8086 and arguably the definition of what is “simple and quick” may have changed. Optimization has been proposed as a way to estimate parameters of latent variable methods where missing data is present in the system[1, 2]; as a way to simultaneously carry out curve resolution and kinetic parameter estimation[3, 4]; and ultimately as a way to completely move out of using empirical regressions to translate spectroscopic information into chemical one[5, 6].

This talk will review these proposals and will focus on the disruptive nature of the last one where the use of a fixed regression model is replaced by the use of real-time optimization and the use of Beer-Lambert’s law -or a modified version of BL.


[1] R.L.N. de la Fuente, S. Garcia‐Munoz, L.T.J.J.o.C. Biegler, An efficient nonlinear programming strategy for PCA models with incomplete data sets, 24 (2010) 301-311.
[2] E.H. Puwakkatiya‐Kankanamage, S. Garcia‐Munoz, L.T.J.J.o.C. Biegler, An optimization‐based undeflated PLS (OUPLS) method to handle missing data in the training set, 28 (2014) 575-584.
[3] W. Chen, L.T. Biegler, S.G. Munoz, An approach for simultaneous estimation of reaction kinetics and curve resolution from process and spectral data, Journal of Chemometrics, 30 (2016) 506-522.
[4] W. Chen, L.T. Biegler, S.G.J.A.J. Munoz, Kinetic parameter estimation based on spectroscopic data with unknown absorbing species, 64 (2018) 3595-3613.
[5] K. Muteki, D.O. Blackwood, B. Maranzano, Y. Zhou, Y.A. Liu, K.R. Leeman, G.L.J.I. Reid, E.C. Research, Mixture component prediction using iterative optimization technology (calibration-free/minimum approach), 52 (2013) 12258-12268.
[6] Z. Shi, J. Hermiller, S.G.J.A.J. Munoz, Estimation of mass‐based composition in powder mixtures using Extended Iterative Optimization Technology (EIOT), (2018).
世話人 杉山 弘和 (内線27227)

第351回化学システム工学専攻公開セミナー 化学企業におけるシミュレーション技術の変遷とデジタル変革

日時
2019年12月5日(木) 13:30-15:30
場所
東京大学工学部3号館大会議室1 (6C07号室)
講演題目 化学企業におけるシミュレーション技術の変遷とデジタル変革
講演者 三菱ケミカル株式会社 上席主幹研究員 竹内 久雄
概要 本発表では化学・素材産業における計算科学・工学の紹介と今後の期待について紹介したい。化学・素材産業では、研究開発における分子設計から製造プラントにおけるリアクターの設計に至るまで、幅広い分野の計算科学・工学が活用されている。これは飛躍的に高速化・廉価化したコンピュータによる所が大きい。一方で、コンピュータの規模や速さが解決手段にならない課題も沢山ある。かかる状況下、昨今ではデータ駆動を軸としたインフォマティクスが急速に広がりつつある。一方、近年、産業界では “デジタル変革”という言葉が一般的になってきた。もともと、計算科学や工学は、最たるデジタル技術であるコンピュータを駆使するものであるが、10年前には“デジタル変革”との接点は語られなかった。近年の“デジタル変革”の流れの中で、計算科学・工学が置かれている環境が大きく変化し、新たな機会と課題が提供されているとも言えよう。
世話人 吉江 建一 (内線27352、kenyoshie@chemsys.t.u-tokyo.ac.jp)

第350回化学システム工学専攻公開セミナー SOLAR THERMAL ENERGY: FROM POWER AT NIGHT TO RENEWABLE JET FUEL

日時
2020年1月7日(火)15:00-16:30
場所
工学部3号館6階6C07室
講演題目 SOLAR THERMAL ENERGY: FROM POWER AT NIGHT TO RENEWABLE JET FUEL
講演者 Professor Wojciech Lipinski
ANU Solar Thermal Group
Research School of Electrical, Energy and Materials Engineering The Australian National University Canberra, ACT 2601 Australia
概要 High-flux solar irradiation obtained with optical concentrators is an excellent source of clean process heat for high-temperature physical and chemical processing. Solar thermal power, the area that has traditionally driven developments in concentrating solar technologies, experiences renewed research interests, primarily in the context of large-scale dispatchable power generation. The area of solar thermochemistry aims at direct thermochemical production of chemical fuels and commodity materials. Cheap and efficient solar production of synthesis gas, the precursor to synthetic drop-in hydrocarbon fuels such as petrol, diesel and kerosene, is an intriguing approach to transform today's fossil-based to tomorrow’s renewable-based transportation sector. In the most ambitious scenario, synthesis gas is obtained from sunlight, water and recycled carbon dioxide. This presentation gives an overview of recent developments in high-temperature solar thermal processing, from basic research to technology applications.

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世話人 大久保達也(内線27348)

第349回化学システム工学専攻公開セミナー 機能性多孔質材料ゼオライトの合成研究に携わって ―耐久性ゼオライトの合成―

日時
2019年11月21日(木)10:30-12:00
場所
工学部3号館6階6C07室
講演題目 機能性多孔質材料ゼオライトの合成研究に携わって ―耐久性ゼオライトの合成―
講演者 佐野庸治
広島大学名誉教授・東京大学工学系研究科特任研究員
概要 分子レベルの大きさの均一なミクロ細孔を有する結晶性アルミノケイ酸塩ゼオライトは、分子ふるい作用、固体酸性、イオン交換能等を有する魅力ある機能性ナノ空間材料であり、様々な分野で用いられている。このゼオライトを機能性材料として利用していく際の最大の課題は、使用 環境下での構造・組成の安定性であり、その耐熱性/耐水熱性の向上を目的に様々な研究が行われている。本講演では、ゼオライトの脱アルミニウム挙動および耐久性ゼオライトの合成における筆者らの成果を紹介する。
世話人 大久保達也、脇原徹(内線27368)

第348回化学システム工学専攻公開セミナー Data utilization for chemical process development

日時
2019年11月25日(月)16:45-18:00
場所
工学部5号館52号講義室
講演題目 Data utilization for chemical process development
講演者 名古屋大学大学院工学研究科物質プロセス工学専攻情報プロセス工学
川尻 喜章 教授
概要 To develop a chemical process, data must be utilized effectively and efficiently. Mathematical models obtained from sufficient and reliable data would streamline development of chemical processes. Data can be often obtained from experiments, which must be designed carefully so that parameters in mathematical models can be obtained accurately.

In this presentation, several case studies will be presented where data science techniques are applied to development of chemical processes. Two approaches, regression and sampling, are introduced for parameter estimation. Several case studies will be discussed including adsorption processes where model parameters are estimated efficiently in a sequential manner.
世話人 杉山 弘和(内線:27227)

第347回化学システム工学専攻公開セミナー Building a bioartificial liver : multi-scale and biomechanical considerations

日時
2019年11月11日(月) 16:00-17:00
場所
東京大学工学部3号館大会議室3 (6C04号室)
講演題目 Building a bioartificial liver : multi-scale and biomechanical considerations
講演者 Prof. Cecile Legallais
CNRS Research Director, Universite de Technologie de Compiegne, UMR CNRS 7338 Biomechanics & Bioengineering, Compiegne, France
(前欧州人工臓器学会会長)

略歴
Dr Cecile Legallais is Head of the CNRS/UTC joint laboratory“Biomechanics & Bioengineering. She coordinates research on “Bioartifical liver”. Her group possesses a large experience on hepatic cells culture (cell lines, primary from human or animal origin) on different 3D scaffolds perfused or not, designed the fluidized bed bioreactor validated in the ANR SUPPLIVER project (2011-2015) and under investigation at lower scale in the PIA RHU iLite (Coordinator: Pr JC Duclos-Vallee). The multidisciplinary nature of her work reveals her expertise in biomedical engineering and tissue engineering for the design of bio-artificial organs, fluid mechanics and microfluidics, transport phenomena, and the interactions between cells and tissues with the biomaterials. Bronze Medal of CNRS in 2003, she published more than 90 papers in peer reviewed journals. She has supervised 22 PhD thesis. She is Past-President of the European Society of Artificial Organs.
概要 Organ on chip or organoids are promising platforms for preclinical studies of new drugs, in predictive toxicology for chemicals, for studies that are more fundamental or for further organ supply. In the presentation we will focus on two major approaches, considering biological behavior in links with biomechanics and mass transfer:

1) The culture of cells in biochips or microstructured devices, in an adequate environment, demonstrated better and prolonged maintenance of cells' functions or differentiation. However, such devices are not easy to handle, which might limit their use in classical laboratories. To overcome this limit, we have developed at UTC a specific platform where 24 biochips can be positioned in series or in parallel. ADME processes can thus be mimicked in such configuration. The biotransformation of xenobiotics achieved in the liver represents usually a key element to assess their toxicity either in the same organ or in others located downstream. Coupled to omics approaches, it may lead to the improved knowledge on the effects of substances alone or in mixture on different intracellular pathways.
2) The culture of cells as spheroids/organoids in alginate beads, for application in bioartificial liver as a supply to failing liver. We evaluated some of the major fucnctions of hepatic cells in such environment and propose a complete set up at human scale for liver supply. We will discuss here the advantages of microencapsulation and the questions regarding the type of cells to be used in such system.
世話人 酒井 康行(内線27073)

第346回化学システム工学専攻公開セミナー 配位状態に着目した二次電池用電解液の設計

日時
2019年9月26日(木) 13:00-14:30
場所
東京大学工学部3号館大会議室1 (6C07号室)
講演題目 配位状態に着目した二次電池用電解液の設計
講演者 山田裕貴
東京大学大学院工学系研究科化学システム工学専攻 講師
概要 電解液は二次電池の性能や安全性を支配する重要な材料である。高いイオン輸送特性に加えて、正極・負極表面でも酸化・還元分解しない高い電気化学安定性が要求される。近年、リチウムイオン電池の更なる高エネルギー密度化(高電圧化・高容量化)・高安全化や次世代二次電池概念の実用化が強く求められており、電解液に要求される機能・性質はより高度化・多様化している。これまで電解液を構成する溶媒と塩の種類に着目した二次元的な材料探索が網羅的に行われてきたが、要求に耐え得る材料は見いだされなかった。本講演では、第3の設計軸として「イオン・溶媒の配位状態」に着目した新たな電解液機能の開拓について紹介するとともに、電解液の高機能化がもたらす二次電池の高付加価値化、高性能化について議論する。
世話人 山田 淳夫(内線27295)

第345回化学システム工学専攻公開セミナー Future Perspectives of Process Automation

日時
2019年10月15日(火) 10:30-12:00
場所
東京大学工学部3号館大会議室1(6C07号室)
講演題目 Future Perspectives of Process Automation
講演者 Dr. Isuru A. Udugama
Carlsberg Postdoctoral Fellow
PROSYS
Department of Chemical and Biochemical Engineering Technical University of Denmark
概要 Refineries, Chemical producers as well as bioprocess industries have been a driving force behind the development of process automation technologies. The primary promise of process automation is the capability to deliver incremental gains in capacity and/or efficiency without the need for costly equipment upgrades, while inherently making processes safer. This is also the case at the advanced regulatory layer of process control, where concepts such as Industry 4.0 and technologies based on Artificial Neural Networks (ANN) promise noticeable improvements in performance in comparison to the traditional and established fundamental/knowledge-based control structures such a model predictive control (MPC).
The objective of this talk is to put these two general trends of ANN and model based control into perspective by taking a “helicopter” view of their current states and inherent limitations, while focusing on specific practical industrial examples. Building on these findings, a future perspective of these two general trends will be given, including projects currently underway at DTU PROSYS and BIOPRO Strategic research consortium to counter some of these limitations identified. The talk will be concluded by briefly looking at how a systems thinking approach can be used to find the best value proposition when implementing control solutions and analysing other emerging process control technologies.
世話人 杉山 弘和(内線:27227)