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第441回化学システム工学専攻公開セミナー 多孔質材料のフロンティア / Frontiers in Porous Materials

日時
2026年3月6日（金）/ 10:30-12:00
場所
工学部5号館1階51号講義室
講演題目 多孔質材料のフロンティア / Frontiers in Porous Materials
講演者 久保 優 (広島大学 先進理工系科学研究科 准教授)
茂木 堯彦 (静岡大学 学術院工学領域 講師)
伊與木 健太 (東京大学 大学院新領域創成科学研究科 准教授)
Zhendong Liu (Associate Professor, Department of Chemical Engineering,
Tsinghua University)
村岡 恒輝 (東京大学 大学院工学系研究科 助教)
Ching-Tien Chen (Assistant Professor, Department of Chemical
Engineering, National Tsing Hua University)
概要 多孔質材料は、これまで人類が直面したさまざまな課題の解決に重要な役割を果たしてきた。 さらに、持続可能な社会の実現に向けた今後の地球規模の課題においても、その貢献が期待されている。 本セミナーでは、6名の研究者が多孔質材料に関する最新の研究成果を多角的な視点から紹介し、最先端の研究動向と将来に向けた新たな可能性を探る。

Porous materials have long played a vital role in addressing humanity’s challenges and are expected to contribute to solving future global issues for sustainability. In this seminar, six researchers will present their latest studies on porous materials from diverse perspectives, highlighting both the frontiers of current research and the opportunities these key materials offer for the future.
世話人 伊與木健太、村岡恒輝（内線27286）

第440回化学システム工学専攻公開セミナー Moving from End-of-Pipe Solutions Towards Safe-and-Sustainable-by-Design

日時
2025年11月11日（火）11:00-12:00
場所
工学部3号館6階6C07
https://u-tokyo-ac-jp.zoom.us/j/82017433557?pwd=f8tpcmhRVtUulxR7cJVkFgJghaBqaM.1
Meeting ID: 820 1743 3557
Passcode: 385659
講演題目 Moving from End-of-Pipe Solutions Towards Safe-and-Sustainable-by-Design
講演者 Dr. Zhanyun Wang
Empa (Swiss Federal Laboratories for Materials Science and Technology)

Bio:
Dr. Zhanyun Wang is an environmental chemist by training, and his research interests focus primarily on understanding the life cycles and risks of various anthropogenic chemicals in the technosphere and natural environment. He is also interested in exploring novel and pragmatic approaches to advancing sound chemicals management, enabling a sustainable circular economy, and strengthening the science-policy interface on chemicals and waste. Since 2012, he has been active in the science-policy interface of international chemicals and waste management. He has led more than 10 technical reports commissioned by UNEP, OECD, and several national governments and has participated, as an observer, in the negotiations under the Basel, Rotterdam, and Stockholm Conventions and the Strategic Approach to International Chemicals Management (SAICM).
概要 Today, over 95% of manufactured goods depend on chemical and material technologies. However, the prevailing linear model of production, use, and disposal—combined with inadequate management—leads to significant losses of chemicals and materials throughout their life cycle, resulting in pollution and adverse impacts on human health and ecosystems. As such, reliance on end-of-pipe solutions is no longer sufficient. This presentation will begin with an overview of the multifaceted impacts of chemicals on Earth systems, highlighting ongoing efforts to define safe and just Earth system boundaries. It will then explore the solution space, focusing on the safe-and-sustainable-by-design framework. Particular attention will be given to current challenges and opportunities in operationalizing this approach to support a more sustainable and resilient future.
世話人 Sara Badr

第439回化学システム工学専攻公開セミナー What can solid state chemistry do for catalysis?

日時
2025年11月28日（金）15:00-16:30
場所
工学部5号館第1輪講室（233号室）
講演題目 What can solid state chemistry do for catalysis?
講演者 Yoji Kobayashi（小林洋治）
Chemistry Program, Division of Physical Science and Engineering
King Abdullah University of Science and Technology (KAUST)

Bio:
Yoji Kobayashi obtained his B.A. (Honors) in organometallic chemistry with David Glueck (Dartmouth College, USA), and in 2002 his PhD in inorganic materials with Thomas Mallouk (Penn State, USA). After postdoctoral work on metal organic frameworks with Jeffrey Long (UC Berkeley), he joined Kyoto University in 2010 as an Assistant Professor, and later Lecturer and Associate Professor. Since 2021, Yoji Kobayashi has been at KAUST, hosting his group in solid state chemistry and catalysis while also currently chairing the Chemistry Program at KAUST. His research focuses on various hydride/nitrides, intermetallics, high-entropy systems, and other oxides for catalysis and structural studies.
概要 Abstract:
Heterogeneous catalysts have largely been characterized as metal nanoparticles supported on relatively innocent or simple supports such as Al2O3, SiO2, carbon, and others. Hence, the catalyst/support repertoire has been somewhat limited over the past hundred years, despite the breadth of the field and increasing demands from society. As a solid state chemistry group, we focus on new hydrides, carbides/nitrides, intermetallics, mixed anion systems, and high-entropy materials for reactions and catalysis. We have previously identified that hydrides in solids are unusually exchangeable, leading to many applications in catalysis and inorganic material synthesis. Additionally, intermetallics, an extremely diverse group of materials, exhibit many unusual properties due to their electronic structure. Together, these form an immense undertapped reserve of materials for new catalysts and potential new chemical transformations. We will present some recent results on these materials.
世話人 北田　敦

第438回化学システム工学専攻公開セミナー ゼオライト薄膜の合成手法と分離膜・膜反応器としての応用

日時
2025年11月19日（水）13:00-14:30
場所
工学部3号館6階大会議室3(6B04)
講演題目 ゼオライト薄膜の合成手法と分離膜・膜反応器としての応用
講演者 酒井求（早稲田大学　理工学術院先進理工学部応用化学科 講師）
Motomu Sakai(Department of Applied Chemistry, Waseda University)
概要 ゼオライトや金属有機構造体といった結晶性多孔体は、ガス吸着や触媒、分離膜の材料として広く用いられており、 今なお合成および利用に関する研究が活発に行われている。 講演者は、これまでにゼオライト薄膜の合成手法開発、薄膜の微細構造評価技術開発、分離膜としての利用に関する研究を行ってきた。 また、触媒反応と膜分離を組み合わせた膜反応器の構築および実証も進めてきた。 本講演では、これまでの研究成果を紹介すると共に、結晶性多孔質分離膜の今後の展望を述べる。
世話人 杉山 弘和（内線：27227）

第437回化学システム工学専攻公開セミナー Designing a Future Plastic Industry Addressing Triple Planetary Crisis

日時
2025年10月23日（木）16:00-17:30
場所
工学部3号館6階6C06 /
Zoom: https://u-tokyo-ac-jp.zoom.us/j/81326052824?pwd=ihZf9fQN4XeYyrIxq0Dzcly1TAXmFi.1
Meeting ID: 813 2605 2824
Passcode: 705339
講演題目 Designing a Future Plastic Industry Addressing Triple Planetary Crisis
講演者 Dr. Jing Huo
ETH Zurich in Switzerland

Bio:
Dr. Jing Huo is a Postdoctoral Researcher at the Chair of Ecological Systems Design at ETH Zurich in Switzerland, where she also completed her PhD and master's degree. With a foundation in environmental engineering, Jing spent four years as a sustainability engineer in the chemical industry before returning to academia, bringing real-world insights into her research. Her work focuses on enabling the net-zero transition of the global chemical industry and analyzing potential trade-offs on other environmental impacts. She places particular emphasis on the role of alternative feedstocks in decarbonizing chemical production. Taking a system perspective, she examines the complex interconnections between chemical production networks, supply chains, and broader industrial ecosystems. She employs an interdisciplinary approach combining dynamic and prospective life cycle assessment (LCA), material flow analysis (MFA), and integration with integrated assessment models (IAM) to develop implementable pathways toward sustainable chemical systems that consider both local and global implications.
概要 Abstract:
The global plastic industry stands at a crossroads. With global production set to reach 1000 Mt (more than double from today) by 2050, the industry contributes significantly to the triple planetary crisis of climate change, biodiversity loss, and pollution under the business-as-usual pathway due to its heavy reliance on fossil resources. Can we redesign the plastic industry to achieve net-zero emissions while addressing these interconnected environmental challenges? In this presentation, Jing will discuss the feasibility and trade-offs of transforming global plastic production through alternative feedstocks and complementary strategies. We begin by examining the prospective and regionalized availability and environmental impacts of two promising alternatives: captured CO₂ from industrial sectors and biomass from agricultural and forest residues. Our analysis reveals substantial global potential for both feedstocks, but with significant regional variations and environmental trade-offs, particularly in land-use-related biodiversity loss. Building on these feedstock assessments, we developed PolyLOP (Polymer Lifecycle Optimization Program), a comprehensive linear optimization model that integrates feedstock availability and environmental impacts. Through PolyLOP, we demonstrate that achieving net-zero plastic production is technically feasible using combinations of alternative feedstocks, enhanced recycling, and carbon capture technologies. However, success hinges upon abundant biomass resources and renewable electricity, and comes with important trade-offs in the other dimensions of the planetary crisis, namely particulate matter-related human health impacts and land-use-related biodiversity loss. Regional strategies vary dramatically across our scenarios. Brazil can leverage abundant biomass resources but faces biodiversity challenges, while Japan favors CO₂-based production routes due to clean electricity projected under net-zero scenarios and limited biomass availability. These findings reveal that no universal solution exists. Sustainable plastic production requires tailored regional approaches and international cooperation. This presentation will explore the methodological innovations combining integrated assessment models (IAMs), life cycle assessment (LCA), and optimization modeling used to navigate these complex trade-offs, and discuss implications for industrial ecology research and net-zero industrial transitions.
世話人 Sara Badr

第436回化学システム工学専攻公開セミナー (Lecture 1) Messages in a vesicle: mRNA therapy for cancer and other human diseases / (Lecture 2) Friends or Foes? Targeting Macrophages for Cancer Immunotherapy and Drug Delivery

日時
2025年10月10日（金）15:00-17:00
場所
工学部5号館56講義室
講演題目 (Lecture 1) Messages in a vesicle: mRNA therapy for cancer and other human diseases / (Lecture 2) Friends or Foes? Targeting Macrophages for Cancer Immunotherapy and Drug Delivery
講演者 (Lecture 1)：
Betty Kim, MD, Ph.D,
Professor, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
https://faculty.mdanderson.org/profiles/yonsonbetty_kim.html

(Lecture 2)：
Wen Jiang, MD, Ph.D.
Associate Professor, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
https://faculty.mdanderson.org/profiles/wen_jiang.html
概要 (Lecture 1)：
Messenger RNA (mRNA) therapeutics are emerging as a versatile platform for regenerative medicine, oncology, and genetic disease correction, but their translation is limited by challenges in safe and efficient delivery. In this seminar, I will discuss our efforts to harness extracellular vesicles (EVs) as natural carriers for therapeutic mRNA. In our early work, we demonstrated that EV-mediated delivery of tumor suppressor mRNA could restore lost gene function and suppress tumor growth in preclinical cancer models (Nature Biomedical Engineering, 2020). We subsequently applied this strategy to regenerative medicine, showing that EVs loaded with mRNA encoding collagen stimulate dermal cells to produce new collagen and reduce skin wrinkles, highlighting opportunities in both cosmetic and therapeutic tissue repair (Nature Biomedical Engineering, 2023). Most recently, we are extending this platform to rare genetic disorders, with a focus on Duchenne muscular dystrophy (DMD), where delivery of full-length dystrophin mRNA via engineered EVs has produced encouraging preclinical results (manuscript under revision at Nature Biomedical Engineering). Together, these studies illustrate the translational promise of EV-mRNA therapeutics, showcasing a pipeline that spans cancer therapy, regenerative applications, and inherited diseases.

(Lecture 2)：
Macrophages represent a central axis in cancer nanomedicine and immunotherapy: they can eliminate tumor cells through phagocytosis but also sequester therapeutic nanoparticles in the liver, limiting delivery. In this seminar, I will present engineering strategies to reprogram macrophage activity to selectively enhance antitumor immunity while reducing off-target clearance. I will begin with our development of MUSIC (Nature Nanotechnology 2022), an ultrasound-guided platform that delivers the STING agonist cGAMP into antigen-presenting cells with spatiotemporal precision to amplify innate immune activation. I will then discuss a microbial-inspired CD47-listeriolysin O (LLO) fusion (Nature Cancer 2025) that disrupts the “don’t eat me” checkpoint to drive robust tumor cell phagocytosis. Finally, I will highlight our recent work on MARCO blockade (Nature Nanotechnology 2023), which reduces hepatic macrophage uptake of nanoparticles and thereby enhances tumor delivery and therapeutic efficacy. Together, these efforts illustrate a convergent design strategy to reshape macrophage biology, transforming them from foes into allies for cancer nanomedicine and immunotherapy.
世話人 太田誠一（内線20483）

第435回化学システム工学専攻公開セミナー Why Models Need Data: Ensuring Reliability in Pharmaceutical Process Design

日時
2025年10月14日（火）13:00-15:00
場所
工学部3号館6階大会議室1&2
講演題目 Why Models Need Data: Ensuring Reliability in Pharmaceutical Process Design
講演者 Dr. Salvador Garcia Muñoz
Executive Director Engineering, Product Research & Development
Eli Lilly and Company
概要 Pharmaceutical development increasingly relies on mechanistic models to guide process understanding, optimization, and regulatory communication. However, models do not exist in isolation—they are inherently dependent on data. This talk explores the symbiotic relationship between data and models, emphasizing how uncertainty in data propagates through parameter estimation and ultimately affects the reliability of design spaces derived from models. Rather than viewing uncertainty as a limitation, we highlight how a thoughtful characterization of data variability enables the construction of realistic models with the appropriate level of granularity—models that are not only scientifically sound but also practically useful for decision-making and regulatory confidence.
世話人 杉山 弘和（内線：27227）

第434回化学システム工学専攻公開セミナー 研究に役立つレーザ技術・イメージング技術の開発

日時
2025年10月1日（水）16:00-17:30
場所
工学部5号館第4輪講室
講演題目 研究に役立つレーザ技術・イメージング技術の開発
講演者 木島公一朗
（ピンポイントフォトニクス株式会社）

経歴：
所属：ピンポイントフォトニクス株式会社　代表取締役
経歴：1986年 東京工業大学　工学部　生産機械工学科　卒業
　　　1988年 東京工業大学　理工学研究所　生産機械工学専攻　修士課程修了
　　　1988年 ソニー株式会社入社
　　　2002-2003年　UCLA　Bahram Jalali研究室留学
　　　2012年　東京工業大学　理工学研究所　電気電子工学専攻
　　　　　　博士(工学)課程修了(社会人博士課程)
　　　2018年　ソニー株式会社退社
　　　2018年ー現在　ピンポイントフォトニクス株式会社
概要 講演者は、大手電機メーカにおいて、レーザ光源開発、光ディスクシステム開発に従事した後、イメージング技術・レーザ技術のバイオ・メディカル領域への適用を目指し、がん治療領域、整形外科領域などでニーズ調査、研究、開発を行ってきた。さらに、ピンポイントフォトニクス株式会社設立後も、イメージング技術・レーザ技術のバイオ・メディカル領域への適用のためのニーズ調査に立脚した研究開発を行い、成果は一流学術誌への掲載にも至っている。本講演においては、ニーズ調査の経験から製品開発に至った経緯を失敗例も含めてご紹介するとともに、未踏の研究ニーズに対してどのようなアプローチが有効かについてご紹介させていただきます。
世話人 伊藤大知（内線21425）

第433回化学システム工学専攻公開セミナー Dynamics of Proton Transfer Events in Aqueous Acidic and Basic Solutions and Nonlinear Vibrational Spectroscopy from Ab Initio Molecular Dynamics

日時
2025年7月30日（水）15:00-16:30
場所
工学部3号館大会議室2（6C06号室）
講演題目 Dynamics of Proton Transfer Events in Aqueous Acidic and Basic Solutions and Nonlinear Vibrational Spectroscopy from Ab Initio Molecular Dynamics
講演者 Prof. Amalendu Chandra
Department of Chemistry, Indian Institute of Technology Kanpur
https://home.iitk.ac.in/~amalen/
概要 Aqueous acidic and basic solutions involve proton transfer reactions occurring at a rather fast rate at room temperature. We will discuss our recent theoretical work on the dynamics of these proton transfer events and nonlinear vibrational spectroscopy of aqueous solutions of strong acids and bases. Our approach is based on ab initio molecular dynamics simulations and time correlation function approaches of higher order vibrational spectroscopy. We will present calculations of the rate constants of proton transfer events including proton rattling and proton translocation events, and connect them to the observables of vibrational spectroscopy. It will be shown that as the proton transfer takes place, the frequency of the reactive stretch mode of a hydronium ion undergoes a passage from mid-IR to THz region due to conversion of the initial covalent bond to a hydrogen bond upon proton transfer. The time scale of the evolution of this frequency change, which can be extracted from nonlinear vibrational spectroscopy, can be linked to the underlying dynamics of proton transfer events. Toward the end, we will also discuss some of our recent theoretical work on terahertz sum frequency generation (THz-SFG) spectroscopy of aqueous surfaces.
世話人 中山哲（内線27270）

第432回化学システム工学専攻公開セミナー Tailoring interface structures to improve electrocatalytic CO2 reduction and waste conversion

日時
2025年6月24日（火）10:00-11:30
場所
工学部5号館第1輪講室（233号室）
講演題目 Tailoring interface structures to improve electrocatalytic CO2 reduction and waste conversion
講演者 Dr. Christian M. Pichler
TU Wien, Institute of Applied Physics
概要 For improving electrocatalytic reactions a great portion of research is focussing on the development of novel catalytic materials to increase activity and selectivity. Effects of electrolyte composition and orientation of ions on the electrochemical double layer can, however, also play a decisive role in determining the catalytic performance of a system.
Examples from two different electrocatalytic systems will be demonstrated, where utilization of additives and tuning of electrolyte composition, proved to be beneficial for increasing product yields and selectivity for CO2 reduction and conversion of plastic waste derived substrates.
Simulation and modelling approaches were conducted to complement the mechanistic understanding of the reaction mechanisms and structural alterations taking place at the solid liquid interface.
世話人 高鍋和広（内線21195）