第392回化学システム工学専攻公開セミナー Real time monitoring and control of downstream processing of biopharmaceuticals
- 日時
- 2023年7月12日（水）10:00-11:00
- 場所
- 工学部3号館6C07号室
| 講演題目 | Real time monitoring and control of downstream processing of biopharmaceuticals |
|---|---|
| 講演者 | Prof. Alois Jungbauer Department of Biotechnology University of Natural Resources and Life Sciences Vienna (BOKU), Austria Austrian Centre of Industrial Biotechnology |
| 概要 | The biopharmaceutical industry is still running in batch mode, mostly because it is a highly regulated industry sector. In the past, sensors were not readily available and in-process control was mainly executed off-line. The most important product parameters are quantity, purity and potency besides adventitious agents and bioburden. In order to ensure the quality of pharmaceuticals initiatives such as Process Analytical Technologies, Quality by Design and Continuous Integrated Manufacturing have been established. The vision must be that these initiatives together with technology development pave the way for process automation and autonomous bioprocessing without any human intervention. Then a real-time release would be realized leading to a highly predictive and robust biomanufacturing system. The steps toward such automated and autonomous bioprocessing will be presented in context of monitoring and control. Starting from statistical treatment of single and multiple sensors, establishing soft sensors with predictive chemometrics and hybrid models. A scenario is described how to integrate soft sensors and predictive chemometrics into modern process control. This will be exemplified by selective downstream processing steps such as chromatography and membrane filtration, the most common unit operations for separation of biopharmaceuticals. |
| 世話人 | Sara Badr（内線26876） |