第301回化学システム工学専攻公開セミナー Computer Aided Process Engineering in the Pharmaceutical Industry
- 日時
- 2017年5月30日（火） 10:45～12:00
- 場所
- 東京大学工学部3号館小会議室１（6C02号室）
| 講演題目 | Computer Aided Process Engineering in the Pharmaceutical Industry |
|---|---|
| 講演者 | Dr. Salvador Garcia-Munoz Computer Aided Process Engineering, Small Molecule Design and Development, Eli Lilly and Company |
| 概要 | Trends and changes in the regulatory environment have driven the pharmaceutical sector to embrace changes in the approach to process development. Shifting from an empirical and mostly experimental approach, to a strategy that seeks deeper process understanding. Specifically, the process systems engineering field has found many applications for straightforward application of model and simulation of unit operations. In a span of 10 years, the deterministic modeling of manufacturing processes has gained substantial application in pharmaceutical process development substituting the more traditional empirical response surface approaches. In spite of the apparent replacement of statistics with deterministic models, there is still a significant overlap between these two fields. The overlap between statistics and deterministics is critically important especially when the model is being developed with marginal prior information. In these early stages, where the data is uncertain and model even more; the scientist must seek the application of statistical concepts that acknowledge the form and structure of the (potentially very complex) deterministic model. Computer Aided Process Engineering (CAPE) is presented as a practical implementation of modeling and simulation technology enhanced by optimization and statistics. CAPE enables the pharmaceutical scientist to make informed decisions for complex scenarios, using all the prior knowledge available as long as this is programed into the form of a mathematical model. |
| 世話人 | 杉山 弘和（内線27227） |